
The European Medicines Agency has granted conditional marketing authorization for Durveqtix, a gene therapy for severe and moderately severe hemophilia B, and Adzynma, an enzyme replacement therapy for congenital thrombotic thrombocytopenic purpura, addressing unmet medical needs in these rare conditions.


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The European Medicines Agency has given the go-ahead for Durveqtix to treat hemophilia B in adults and to Adzynma for patients with congenital thrombotic thrombocytopenic purpura.

EMA Authorizes Hemophilia B Gene Therapy

european-medicines-agency-approves-two-novel-therapies-hemophilia-b-gene-therapy-and-enzyme-replacement-for-congenital-thrombotic-thrombocytopenic-purpura


European Medicines Agency Approves Two Novel Therapies: Hemophilia B Gene Therapy and Enzyme Replacement for Congenital Thrombotic Thrombocytopenic Purpura


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Chicken fibroblasts can be efficiently transdifferentiated into muscle cells and simultaneously induced to deposit fat, enabling the production of cultured meat with customizable intramuscular fat content.


Current studies on cultured meat mainly focused on the muscle tissue reconstruction in vitro, but lack the formation of intramuscular fat which is a crucial factor in determining taste, texture and nutritional contents. Therefore, incorporating fat into cultured meat is of superior value. In this study, we employed the myogenic/lipogenic transdifferentiation of chicken fibroblasts in 3D to produce muscle mass and deposit fat into the same cells without the co-culture or mixture of different cells or fat substances. The immortalized chicken embryonic fibroblasts were implanted into the hydrogel scaffold and the cell proliferation and myogenic transdifferentiation were conducted in 3D to produce the whole-cut meat mimics. Compare to 2D, cells grown in 3D matrix showed elevated myogenesis and collagen production. We further induced fat deposition in the transdifferentiated muscle cells and the triglyceride content could be manipulated to match and exceed the levels of chicken meat. The gene expression analysis indicated that both lineage-specific and multi-functional signalings could contribute to the generation of muscle/fat matrix. Overall, we were able to precisely modulate muscle, fat, and extracellular matrix contents according to balanced or specialized meat preferences. These findings provide new avenues for customized cultured meat production with desired intramuscular fat contents that can be tailored to meet the diverse demands of consumers. 

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Graphical Abstract

### Competing Interest Statement

The authors have declared no competing interest.

 [1]: pending:yes

Transdifferentiation of fibroblasts into muscle cells to constitute cultured meat with tunable intramuscular fat deposition

chicken-fibroblasts-transdifferentiated-into-muscle-cells-with-tunable-intramuscular-fat-deposition-for-cultured-meat-production


Chicken Fibroblasts Transdifferentiated into Muscle Cells with Tunable Intramuscular Fat Deposition for Cultured Meat Production



AbDiffuser introduces a novel approach to generating antibodies by leveraging domain knowledge and physics-based constraints, resulting in high-quality structures and sequences.


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AbDiffuser: Full-Atom Generation of Antibodies
